Mainly because diazepam and its metabolites may be existing in human breast milk for extended amounts of time just after acute use, patients ought to be suggested to not breastfeed for an proper time period following receiving procedure
benzhydrocodone/acetaminophen and diazepam the two increase sedation. Stay clear of or Use Alternate Drug. Limit use to patients for whom option treatment method possibilities are insufficient
withdrawal reactions, including seizures, that may be existence-threatening; use gradual taper when discontinuing therapy to cut back withdrawal reactions possibility
地西泮在口服後，迅速被身體吸收，藥效很快開始，以靜脈注射，藥效更快。地西泮經肝臟代謝，其代謝物經腎臟排泄，只有極少量的地西泮沒有被代謝便排泄。
levonorgestrel oral/ethinylestradiol/ferrous bisglycinate will enhance the degree or effect of diazepam by decreasing metabolism.
are breastfeeding or decide to breastfeed. VALIUM passes into your breast milk and could damage your little one. Talk to your Health care supplier about The easiest method to feed your little one if you take VALIUM. Will not breastfeed while getting VALIUM.
It's got a presently acknowledged health-related use in cure in the United States. Abuse might result in limited Actual physical dependence or psychological dependence relative to People in program 3.
On account of extended-performing metabolite, not considered a drug of choice within the elderly; related to falls
ethinylestradiol will enhance the degree or outcome of diazepam by Mechanism: decreasing metabolism. Use Warning/Check. Ethinyl estradiol might inhibit the clearance of benzodiazepines that endure oxidation, thus escalating serum concentrations of concomitantly administered benzodiazepines.
nevirapine will decrease the level or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
Watch Carefully (1)diazepam increases toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Modify Therapy/Watch Carefully. Research have revealed that The mixture of benzodiazepines and buprenorphine altered the more info same old ceiling effect on buprenorphine-induced respiratory despair, generating the respiratory consequences of buprenorphine seem just like These of entire opioid agonists. There happen to be postmarketing studies of coma and Dying with coadministration of buprenorphine and benzodiazepines.
Diazepam was detected in 26% of conditions of people suspected of driving beneath the impact of medication in Sweden and its Energetic metabolite nordazepam was detected in 28% of conditions. Other benzodiazepines, zolpidem, and zopiclone also were found in large figures. Quite a few motorists experienced blood concentrations far exceeding the therapeutic dose variety, suggesting a higher degree of possible for misuse of benzodiazepines, zolpidem, and zopiclone.
tecovirimat will increase the amount or influence of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Keep an eye on. Tecovirimat is actually a weak inhibitor of CYP2C8 and CYP2C19. Monitor for adverse outcomes if coadministered with delicate substrates of these enzymes.
primidone will lower the level or influence of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.